Rehabilitation Dataset Directory: Dataset Profile

The primary goal of this project was to determine the neurobiologic basis for elevated activity in the contralesional primary motor cortex (PMC). In healthy individuals, unimanual movement (with either the left or right hand) is associated with activity in a network of predominantly contralateral brain regions, including the primary motor cortex. This laterality is often compromised following a middle cerebral artery (MCA) stroke. Neuroimaging studies of these patients have shown that unimanual movements with the effected hand are associated with elevated blood oxygen level dependent (BOLD) signal in both the lesioned and the nonlesioned primary motor cortices. Elevated activity in the contralesional PMC is well-established in chronic stroke patients and is associated with poor motor rehabilitation outcomes. Yet the neurobiologic basis for this aberrant neural activity is equivocal.

One factor that may contribute to elevated activity in the contralesional PMC is increased cortical excitatory tone within the contralesional hemisphere. Another factor that may contribute to elevated activity in the contralesional PMC is a loss of transcallosal inhibition between the hemispheres. 

These two explanations were tested through a cross-sectional investigation of neural function in left MCA stroke patients with mild-moderate right upper extremity impairment and controls matched for age and cardiovascular risk factors. To assess the clinical relevance of these factors on motor dysfunction, the researchers performed a detailed kinematic assessment of movement efficiency, smoothness and compensation.

Stroke, Motor dysfunction, Functional MRI, Anatomical Imaging, Magnetic resonance (MR) spectroscopy, Interleaved transcranial magnetic stimulation (TMS)/MRI, Single hemisphere paired-pulse TMS, Bi-hemispheric paired-pulse TMS

Medical University of South Carolina

Stroke (left middle cerebral artery ischemic stroke), Depression, Anxiety disorders

Mental health disability measures: Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR 16), Patient Health Questionnaire (PHQ-9), Beck Depression Inventory, State Anxiety Inventory, Trait Anxiety Inventory), Rasch-modified Fugl-Meyer upper extremity score

Grip strength, Grasp, Fugl-Meyer Assessment of Motor Recovery after Stroke, Wolf Motor Function Test, Step length, Walking speed, Stroke Impact Scale (SIS), Action Research Arm Test

Middle cerebral artery (MCA) stroke, Neural activity, Neuroimaging, Brain stimulation, 3D optical imaging, Kinematics analyses (movement efficiency, movement smoothness, and motor compensation)

Control group and stroke patients: Adults aged 21-80 with at least two cardiovascular risk factors (smoking, high blood pressure, high cholesterol, diabetes, overweight, age (over 55 for men, over 65 for women), family history of stroke).

Stroke patients: left middle cerebral artery ischemic stroke with at least 6 month chronicity, right upper extremity weakness with a Rasch-modified Fugl-Meyer upper extremity score of 20 to 50, ability to voluntarily flex the affected elbow and shoulder from 10-75% of the normal range, and ability to make a fist and relax the affected hand.

n=37 (20 Stroke patients, 17 Control group)

Individual/Patient

North America

United States

All subjects were recruited from the larger Charleston, South Carolina community

NA

Clinical, Survey, Experimental 

2014-16

Data collected over 2 visits:

Visit 1: Screening

Visit 2: Stimulation/Scanning/Written Assessments

For details see methodology   

Wide variety of measures taken and available for both stroke and control participants in study. 

https://www.icpsr.umich.edu/web/ADDEP/studies/37313 

https://www.icpsr.umich.edu/web/ADDEP/studies/37313/datadocumentation 

Restricted-Use:

Researchers must agree to the terms and conditions of a Restricted Data Use Agreement in accordance with ICPSR servicing policies.

Variable level frequencies:

https://www.icpsr.umich.edu/web/ADDEP/studies/37313/variables 

• DS1 Neuroimaging
  
• DS2 Brain Stimulation
• DS3 Quantitative and Behavioral
• DS4 Demographics

• Stroke Recovery in Underserved Populations 2005-2006 (SRUP)
• Anatomical Tracings of Lesions after Stroke (ATLAS)
• Medical University of South Carolina Stroke Data (ARRA)
  
• Stroke Initiative for Gait Data Evaluation (STRIDE)

Data and Documentation:

https://www.icpsr.umich.edu/web/ADDEP/studies/37313/datadocumentation